Ethyl chloroformate → HCID 135474762、化合物
反応式
[CH2:1]([O:3]C(Cl)=O)C.[Cl:7][C:8]1[CH:28]=[C:27]([O:29][CH2:30][CH:31]=[C:32]([Cl:34])[Cl:33])[CH:26]=[C:25]([Cl:35])[C:9]=1[O:10][CH2:11][CH2:12][CH2:13][O:14][C:15]1[CH:24]=[CH:23][C:18]([C:19]([NH:21][OH:22])=[NH:20])=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:7][C:8]1[CH:28]=[C:27]([O:29][CH2:30][CH:31]=[C:32]([Cl:34])[Cl:33])[CH:26]=[C:25]([Cl:35])[C:9]=1[O:10][CH2:11][CH2:12][CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([C:19]2[NH:20][C:1](=[O:3])[O:22][N:21]=2)=[CH:23][CH:24]=1参加物
5
実験手順
90 mg of chloroformic acid ethyl ester in 1 ml of acetone are added dropwise at 5° C. to 400 mg of 4-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propoxy}-N-hydroxy-benzamidine and 127 mg of potassium carbonate in 3 ml of acetone. After 3 hours at 0-5° C., the reaction mixture is poured onto water and extracted with dichloromethane. Concentration of the organic phase and purification over silica gel yield the title compound (compound 1.15).