Methyl L-phenylalaninate hydrochloride → HCID 53816216、化合物

HRID 1822605ノート

反応式

HRID 1822605 の反応式
[Cl:1][CH:2]1[C:10](Cl)([OH:11])[CH:9]=[CH:8][C:4]([C:5]([OH:7])=O)=[C:3]1[OH:13].[ClH:14].[CH3:15][O:16][C:17](=[O:27])[C@H:18]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH2:19].CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C.C(N(CC)CC)C>[CH3:15][O:16][C:17](=[O:27])[C@H:18]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH:19][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([Cl:14])[C:10]([OH:11])=[C:2]([Cl:1])[C:3]=1[OH:13]

参加物

7

反応物 4

HCID 75736Methyl L-phenylalaninate hydrochlorideHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 69621019HCID 69621019、化合物

生成物 1

HCID 53816216HCID 53816216、化合物収率 63.1%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8471Triethylamine溶媒

実験手順

To a solution of 3,4-dichloro-2,4-dihydroxybenzoic acid (17 g), L-phenylalanine methyl ester hydrochloride (19.8 g), WSC.HCl (17.6 g) and HOBT (12.4 g) in DMF (70 ml) was added dropwise triethylamine (12.8 ml) at room temperature, and the mixture was stirred for 16 hours. Then, the mixture was post-treated in the same manner as in the above Example 1, (Step 5) to give the title compound (18.32 g, yield 57%).

後処理

  1. additionThen, the mixture was post-treated in the same manner as in the above Example 1, (Step 5)

出典と根拠

ORDレコード
ord-a7e1308cf54448cca57929d0b63ed123
出典データセット
uspto-grants-2006_05
特許番号
USRE039088E1

反応ノート

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