Tetrahydrofuran → HCID 86590230、化合物

HRID 1822644

反応式

HRID 1822644 の反応式
[O-]CCCC.[K+].C1COCC1.[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=1[C:20]1[CH:24]=[CH:23][N:22]([CH2:25][C:26]([O:28][CH2:29][CH:30]=[CH2:31])=[O:27])[N:21]=1.[Cl:32][C:33]1[N:37]([CH3:38])[N:36]=[C:35]([C:39]([F:42])([F:41])[F:40])[C:34]=1[C:43](Cl)=[O:44]>O>[F:19][C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([F:12])[C:14]=1[C:20]1[CH:24]=[CH:23][N:22]([C:25](=[C:43]([C:34]2[C:35]([C:39]([F:42])([F:41])[F:40])=[N:36][N:37]([CH3:38])[C:33]=2[Cl:32])[OH:44])[C:26]([O:28][CH2:29][CH:30]=[CH2:31])=[O:27])[N:21]=1

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 27945855-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonyl chlorideHCID 22169508Allyl 2-(3-(2,6-difluorophenyl)pyrazol-1-yl)acetateHCID 23699084Potassium butoxide

生成物 1

HCID 86590230HCID 86590230、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Potassium butoxide (0.5 g) was added to a THF (10 mL) solution of allyl 2-{3-(2,6-difluorophenyl)pyrazol-1-yl}acetate (0.5 g) and 5-chloro-1-methyl-3-trifluoromethylpyrazole-4-carbonyl chloride (0.44 g) at 0° C., and stirred for 5 minutes. Water (5 ml) was added thereto, and then extracted with diluted hydrochloric acid and ethyl acetate. After the organic layer was dried over anhydrous magnesium sulfate, and then concentrated, and the resulting concentrate was purified through silica gel column chromatography (chloroform) to obtain the intended product, Compound No. I-133 (0.89 g).

後処理

  1. extractionextracted with diluted hydrochloric acid and ethyl acetate
  2. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated
  4. concentrationthe resulting concentrate
  5. customwas purified through silica gel column chromatography (chloroform)
  6. customto obtain the intended product, Compound No

出典と根拠

ORDレコード
ord-1b13ba0bcd2e41769c1748fcfab9e61a
出典データセット
uspto-grants-2006_05
特許番号
US07037880B2

関連ノート

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