Acetophenone → 2-Phenyl-[1,6]naphthyridine-4-carboxylic acid

HRID 1822748ノート

反応式

HRID 1822748 の反応式
CC(C)(C)C([NH:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][C:7]=1[CH2:12][C:13](=[O:19])C(OCC)=O)=O.[OH-:22].[K+].[C:24]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)(=O)[CH3:25]>C(O)C.O>[C:27]1([C:24]2[N:5]=[C:6]3[CH:11]=[CH:10][N:9]=[CH:8][C:7]3=[C:12]([C:13]([OH:19])=[O:22])[CH:25]=2)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

参加物

6

反応物 3

HCID 7410AcetophenoneHCID 14797Potassium HydroxideHCID 54422680HCID 54422680、化合物

生成物 1

HCID 106821072-Phenyl-[1,6]naphthyridine-4-carboxylic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A mixture of 3.59 g of ethyl 4-trimethylacetamido-3-pyridylpyruvate, 2.89 g of potassium hydroxide in 10 mL of ethanol and 40 mL of water is heated at reflux for 2 hours. At this time 3.1 g of acetophenone is added and refluxing is continued for 6 hours. The ethanol is removed in vacuo, the resulting aqueous solution is washed with ether and the aqueous layer is acidified to pH5. The product is collected washed with water and dried to afford (2-phenylpyridino[4,3-b]pyridin-4-yl) carboxylic acid as a white solid.

後処理

  1. temperatureis heated
  2. temperatureat reflux for 2 hours
  3. temperaturerefluxing
  4. customThe ethanol is removed in vacuo
  5. washthe resulting aqueous solution is washed with ether
  6. customThe product is collected
  7. washwashed with water
  8. customdried

出典と根拠

ORDレコード
ord-75a6a76cb61f46a89e1d0134458825cb
出典データセット
uspto-grants-2006_05
特許番号
US07037922B1

反応ノート

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