Sodium Hydroxide → HCID 131725722、化合物

HRID 1822749ノート

反応式

HRID 1822749 の反応式
[C:1]1([C:7]2[N:12]=[C:11]3[CH:13]=[CH:14][N:15]=[CH:16][C:10]3=[C:9]([C:17]([OH:19])=O)[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.F[P-](F)(F)(F)(F)F.[N:27]1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.C1([C@@H](N)CC)C=CC=CC=1.[OH-].[Na+]>CC(N(C)C)=O.ClC(Cl)C.C(N(CC)CC)C>[C:1]1([C:7]2[N:12]=[C:11]3[CH:13]=[CH:14][N:15]=[CH:16][C:10]3=[C:9]([C:17]([NH2:27])=[O:19])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

8

反応物 4

HCID 14798Sodium HydroxideHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 6993773(1S)-1-phenylpropan-1-amineHCID 106821072-Phenyl-[1,6]naphthyridine-4-carboxylic acid

生成物 1

HCID 131725722HCID 131725722、化合物

試薬・触媒・溶媒 3

HCID 63651,1-Dichloroethane溶媒HCID 8471Triethylamine溶媒HCID 31374Dimethylacetamide溶媒

実験手順

To a solution of 250 mg of 2-phenylpyridino[4,3-b]pyridin-4-yl carboxylic acid dissolved in 5 mL of dimethylacetamide and 200 uL of triethylamine is added 500 mg of BOP in 5 mL of dichloroethane followed by 150 mg of (S)-1-phenylpropylamine. The reaction mixture is stirred for 16 hours at room temperature. The reaction mixture is poured onto 50 mL of 1N NaOH and the product is extracted with 25 mL of ethyl acetate. After drying over magnesium sulfate the solvent is removed in vacuo to afford N—[(S)-1-phenyl-1-propyl)]-(2-phenylpyridino[4,3-b]pyridin-4-yl)carboxamide as a solid.

後処理

  1. extractionthe product is extracted with 25 mL of ethyl acetate
  2. dry with materialAfter drying over magnesium sulfate the solvent
  3. customis removed in vacuo

出典と根拠

ORDレコード
ord-9f9a46d99877422791292d7e71a718a4
出典データセット
uspto-grants-2006_05
特許番号
US07037922B1

反応ノート

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