3-(Tetrahydro-furan-2-yl)-acrylonitrile → 3-(Tetrahydrofuran-2-yl)propan-1-amine
反応式
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH:6]=[CH:7][C:8]#[N:9]>C1COCC1.[Ni]>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][CH2:7][CH2:8][NH2:9]参加物
4
実験手順
Raney Ni (approx 1 mL) was added to 3-(tetrahydro-furan-2-yl)-acrylonitrile (0.43 g, 3.5 mmol) in THF (6 mL), the mixture was evacuated then charged with 1 atm H2 (balloon) then stirred overnight. The mixture was recharged with Raney Ni (1 mL) and H2 and stirring was continued an additional 24 hour, until no starting material was evident via TLC. The reaction contents were filtered through a celite plug, that was thoroughly rinsed with MeOH, solvents removed to yield 3-(Tetrahydro-furan-2-yl)-propylamine (51% yield). ESI-MS (m/z) 130 [M+H]+.
後処理
- customthe mixture was evacuated
- additionthen charged with 1 atm H2 (balloon)
- stirringstirring
- waitwas continued an additional 24 hour, until no starting material
- customThe reaction contents
- filtrationwere filtered through a celite plug, that
- washwas thoroughly rinsed with MeOH, solvents
- customremoved
出典と根拠
- ORDレコード
- ord-2ddd2bd9f72c448aa2b9c8b405b6cdd3
- 出典データセット
- uspto-grants-2006_05
- 特許番号
- US07037916B2
反応ノート
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