Ethyl Acetate → Ethyl 2-(4-hydroxyphenoxy)acetate
反応式
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[CH3:2].CCOC(C)=O>[Pd].CCO>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[CH3:2]参加物
5
実験手順
Ethyl-4-benzyloxyphenoxyacetate compound (3.50 g, 12.2 mmol) was placed in a PARR bottle along with EtOAc (75 mL), EtOH (75 mL), and 5% Pd/C (1.20 g) and the mixture placed under 40 psi of H2. The reaction was shaken under pressure for 4 hours after which no starting material remained by TLC. The catalyst was removed by filtration through Celite and the filtrate concentrated in vacuo to give 2.35 g (97%) of the desired phenol. MP
後処理
- customThe catalyst was removed by filtration through Celite
- concentrationthe filtrate concentrated in vacuo
出典と根拠
- ORDレコード
- ord-62689a56859a41dda62a6d0199b13252
- 出典データセット
- uspto-grants-2006_05
- 特許番号
- US07041684B2
反応ノート
読み込み中…