2-[4-[4-Hydroxybut-1-ynyl]phenyl]-7-methylimidazo[1,2-a]pyridine → 2-[4-[4-Hydroxybutyl]phenyl]-7-methylimidazo[1,2-a]pyridine

HRID 1824548

反応式

HRID 1824548 の反応式
[OH:1][CH2:2][CH2:3][C:4]#[C:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]3[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][N:15]3[CH:21]=2)=[CH:8][CH:7]=1>C(O)C.[Pd]>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[N:13]=[C:14]3[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][N:15]3[CH:21]=2)=[CH:10][CH:11]=1

参加物

4

反応物 1

HCID 220155942-[4-[4-Hydroxybut-1-ynyl]phenyl]-7-methylimidazo[1,2-a]pyridine

生成物 1

HCID 220156552-[4-[4-Hydroxybutyl]phenyl]-7-methylimidazo[1,2-a]pyridine収率 92.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The product of Step B, Example 33 (0.3 g) in ethanol (15 mL) was hydrogenated over 5% palladium on barium sulfate (0.06 g) for 4.5 hours. The reaction mixture was filtered and evaporated to afford the title compound (0.282 g).

後処理

  1. filtrationThe reaction mixture was filtered
  2. customevaporated

出典と根拠

ORDレコード
ord-7dabd75f4f5445a89911f985c724bbc0
出典データセット
uspto-grants-2006_05
特許番号
US07041828B2

関連ノート

読み込み中…