Trifluoroacetic acid → (R)-2-Amino-2-(7-methoxy-naphthalen-2-yl)-ethanol
反応式
C(O)(C(F)(F)F)=O.C(OC(=O)[NH:14][C@H:15]([C:18]1[CH:27]=[CH:26][C:25]2[C:20](=[CH:21][C:22]([O:28][CH3:29])=[CH:23][CH:24]=2)[CH:19]=1)[CH2:16][OH:17])(C)(C)C>C(Cl)Cl>[NH2:14][C@H:15]([C:18]1[CH:27]=[CH:26][C:25]2[C:20](=[CH:21][C:22]([O:28][CH3:29])=[CH:23][CH:24]=2)[CH:19]=1)[CH2:16][OH:17]参加物
4
実験手順
A solution of TFA (8 mL) and (R)-[2-hydroxy-1-(7-methoxy-naphthalen-2-yl)-ethyl]-carbamic acid tert-butyl ester (1.268 g) in methylene chloride (24 mL) was stirred for 2 h. After concentration, the residue was neutralized with 10 N NaOH and extracted with methylene chloride. The organic layer was washed with brine, dried over Na2SO4, and concentrated to give the title compound as a solid (860 mg).
後処理
- concentrationAfter concentration
- extractionextracted with methylene chloride
- washThe organic layer was washed with brine
- dry with materialdried over Na2SO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-20d027a6be6a4eb98686000c21426b9f
- 出典データセット
- uspto-grants-2006_05
- 特許番号
- US07045551B2
反応ノート
読み込み中…