Bromine → 5-Bromo-2-methanesulfonyl-6-methoxy-quinoline

HRID 1825858

反応式

HRID 1825858 の反応式
[CH3:1][S:2]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:15][CH3:16])[CH:11]=2)[N:6]=1)(=[O:4])=[O:3].[Br:17]Br.C([O-])(O)=O.[Na+].S([O-])([O-])(=O)=S.[Na+].[Na+]>C(Cl)Cl>[Br:17][C:11]1[C:10]([O:15][CH3:16])=[CH:9][CH:8]=[C:7]2[C:12]=1[CH:13]=[CH:14][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[N:6]2

参加物

6

反応物 4

HCID 24408BromineHCID 24477Sodium ThiosulfateHCID 516892Sodium BicarbonateHCID 112533772-Methanesulfonyl-6-methoxy-quinoline

生成物 1

HCID 221397325-Bromo-2-methanesulfonyl-6-methoxy-quinoline

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 2-methanesulfonyl-6-methoxy-quinoline (237 mg, 1 mole ) in CH2Cl2 was treated with 2 mmoles Br2 and stirred for 1 day. The mixture was poured into a solution of NaHCO3 and sodium thiosulfate. The product was extracted with CH2Cl2. The organic layer was dried and evaporated to afford 5-bromo-2-methanesulfonyl-6-methoxy-quinoline, 287 mg (91%), as white crystals.

後処理

  1. extractionThe product was extracted with CH2Cl2
  2. customThe organic layer was dried
  3. customevaporated

出典と根拠

ORDレコード
ord-7f20759cd5b54619811543bd81248b5d
出典データセット
uspto-grants-2006_05
特許番号
US07049325B2

関連ノート

読み込み中…