Formamidine acetate → 5,7-dimethoxyquinazolin-4(3H)-one
反応式
[NH2:1][C:2]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[C:8]([O:14][CH3:15])[C:3]=1[C:4](OC)=[O:5].C(O)(=O)C.[CH:20](N)=[NH:21]>COCCO>[CH3:15][O:14][C:8]1[CH:9]=[C:10]([O:12][CH3:13])[CH:11]=[C:2]2[C:3]=1[C:4](=[O:5])[NH:21][CH:20]=[N:1]2参加物
4
実験手順
A mixture of methyl 2-amino-4,6-dimethoxybenzoate (16 g), formamidine acetate (24 g) and 2-methoxyethanol (330 ml) was stirred and heated to reflux until all of the starting material had reacted. The mixture was evaporated and the residue was triturated under water (100 ml). The resultant solid was isolated, washed with water and dried under vacuum to give 5,7-dimethoxy-3,4-dihydroquinazolin-4-one (14.5 g); NMR Spectrum: (DMSOd6) 3.82 (s, 3H), 3.86 (s, 3H), 6.5 (s, 1H), 6.7 (s, 1H), 7.9 (s, 1H), 11.7 (br s, 1H).
後処理
- temperatureheated
- temperatureto reflux until all of the starting material
- customhad reacted
- customThe mixture was evaporated
- customthe residue was triturated under water (100 ml)
- customThe resultant solid was isolated
- washwashed with water
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-e1b2d9700060491b95fddc6fae46ead2
- 出典データセット
- uspto-grants-2006_05
- 特許番号
- US07049438B2
反応ノート
読み込み中…