Diethyl Ether → HCID 178481604、化合物

HRID 1826517ノート

反応式

HRID 1826517 の反応式
[CH3:1][N:2]1[C:7](=[O:8])[CH:6]=[C:5]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[N:4]=[C:3]1SC.[N+:17]([O-])([O-:19])=[O:18].[K+].C([O:24]CC)C>S(=O)(=O)(O)O>[OH:24][C:3]1[N:2]([CH3:1])[C:7](=[O:8])[C:6]([N+:17]([O-:19])=[O:18])=[C:5]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[N:4]=1

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 24434Potassium NitrateHCID 155215183-methyl-2-methylsulfanyl-6-pyridin-4-yl-3H-pyrimidin-4-one

生成物 1

HCID 178481604HCID 178481604、化合物

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
70 °C

実験手順

To a stirring solution of 3-methyl-2-methylsulfanyl-6-pyridin-4-yl-3H-pyrimidin-4-one (15.5 mmol) in 40 mL sulfuric acid was added potassium nitrate (62.1 mmol). The reaction was heated to 70° C. for 3 h. Reaction was then added to stirring diethyl ether (400 mL), and precipitate collected by filtration. The precipitate was suspended in water and the pH was adjusted to 3 using sodium hydroxide. The solid was collected by filtration. M+1=249.

後処理

  1. customReaction
  2. additionwas then added
  3. filtrationcollected by filtration
  4. filtrationThe solid was collected by filtration

出典と根拠

ORDレコード
ord-0d9e616a7c984ad496bfa4dee869fc4e
出典データセット
uspto-grants-2006_05
特許番号
US07049318B2

反応ノート

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