Ethyl indole-2-carboxylate → 4-fluoro-1-methyl-1H-indole-3-carbaldehyde
反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH:11]=[O:12])=[CH:5][NH:6]2.[CH2:13](OC(C1NC2C(C=1)=CC=CC=2)=O)C>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH:11]=[O:12])=[CH:5][N:6]2[CH3:13]参加物
3
実験手順
According to the procedure of Preparation 9 (a), except substituting 4-fluoro-1H-indole-3-carboxaldehyde (0.41 g, 2.5 mmole) for the ethyl-indole-2-carboxylate, the title compound (0.24 g, 54%) was prepared as a viscous oil: MS (ES) m/e 178 (M+H)+.
出典と根拠
- ORDレコード
- ord-d928788cda6740eb8747d4e943ef233e
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741339B2
反応ノート
読み込み中…