Hydrochloric Acid → 4-(2-Benzyloxybenzyl)benzyl alcohol

HRID 1826620ノート

反応式

HRID 1826620 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([O:14][C:15]1[CH:31]=[CH:30][CH:29]=[CH:28][C:16]=1[CH2:17][C:18]1[CH:27]=[CH:26][C:21]([C:22](OC)=[O:23])=[CH:20][CH:19]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C(OCC)(=O)C.Cl>O1CCCC1.O>[CH2:7]([O:14][C:15]1[CH:31]=[CH:30][CH:29]=[CH:28][C:16]=1[CH2:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:22][OH:23])=[CH:26][CH:27]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 21226445Aluminium lithium hydrideHCID 21909320Methyl 4-(2-benzyloxybenzyl)benzoate

生成物 1

HCID 688722414-(2-Benzyloxybenzyl)benzyl alcohol収率 98.8%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a suspension of lithium aluminum hydride (0.47 g) in tetrahydrofuran (5 mL) was added dropwise a solution of methyl 4-(2-benzyloxybenzyl)benzoate (2.1 g) in tetrahydrofuran (5 mL) at 0° C., and the mixture was stirred at the same temperature for 1 hour. Ethyl acetate (10 mL) was added to the reaction mixture, and the resulting mixture was stirred for 30 minutes. To the reaction mixture were added water and dilute hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to give 4-(2-benzyloxybenzyl)benzyl alcohol (1.9 g).

後処理

  1. stirringthe resulting mixture was stirred for 30 minutes
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-fbffdfc5a5c74bb391868045d7367541
出典データセット
uspto-grants-2006_05
特許番号
US07053060B2

反応ノート

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