Thionyl Chloride → Quinoline-6-carbonyl chloride hydrochloride

反応式

[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=O)=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:16])=O>>[ClH:16].[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([Cl:16])=[O:13])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 825716-Quinolinecarboxylic acid

生成物 1

HCID 22136358Quinoline-6-carbonyl chloride hydrochloride

実験手順

6-Quinolinecarboxylic acid was refluxed in thionyl chloride for 30 min. The excess thionyl chloride was then removed by rotary evaporation (90° C.) to provide 6-quinolinecarbonyl chloride hydrochloride.

後処理

customThe excess thionyl chloride was then removed by rotary evaporation (90° C.)

出典と根拠

ORDレコード: ord-5e8e16ef0bd94bc1adf34707003c3a29
出典データセット: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07053104B2

反応ノート

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