Nitro-4-(3-fluoro-phenoxymethyl)-benzene → 4-(3-Fluoro-phenoxymethyl)-phenylamine

HRID 1827386ノート

反応式

HRID 1827386 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pt]>[F:18][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[O:11][CH2:10][C:7]1[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=1

参加物

4

反応物 1

HCID 22137955Nitro-4-(3-fluoro-phenoxymethyl)-benzene

生成物 1

HCID 167938064-(3-Fluoro-phenoxymethyl)-phenylamine収率 112.8%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 887Methanol溶媒

実験手順

g (4 mmol) of 1-Nitro-4-(3-fluoro-phenoxymethyl)-benzene in 40 ml methanol is treated with 0.25 g of 5% platinum on charcoal and hydrogenated for 1 h at room temperature and normal pressure. The catalyst is filtered and the solution evaporated to yield 0.98 g of the crude title compound as yellow oil. MS: m/e=218.3 (M++H).

後処理

  1. filtrationThe catalyst is filtered
  2. customthe solution evaporated

出典と根拠

ORDレコード
ord-e98f04ef2f194a63ad001a25b639b2ca
出典データセット
uspto-grants-2006_05
特許番号
US07053245B2

反応ノート

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