1,3-Dimethyl-1H-pyrazole-5-carbonitrile → (1,3-Dimethyl-1H-pyrazol-5-yl)methanamine

HRID 1827504ノート

反応式

HRID 1827504 の反応式
[CH3:1][N:2]1[C:6]([C:7]#[N:8])=[CH:5][C:4]([CH3:9])=[N:3]1>[Pd].C(O)C>[CH3:1][N:2]1[C:6]([CH2:7][NH2:8])=[CH:5][C:4]([CH3:9])=[N:3]1

参加物

4

反応物 1

HCID 27362971,3-Dimethyl-1H-pyrazole-5-carbonitrile

生成物 1

HCID 1257670(1,3-Dimethyl-1H-pyrazol-5-yl)methanamine収率 90%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A suspension of 2,5-Dimethyl-2H-pyrazole-3-carbonitrile (654 mg, 5.4 mmol) and 10% palladium on carbon (200 mg) in ethanol (15 mL) was shaken in a Parr hydrogenation apparatus under 45 psi H2 for 17 hr. The mixture was filtered through celite and the filtrate was concentrated under reduced pressure to give 608 mg of an oil which was used without any further purification. 1H NMR (CDCl3) δ 5.91 (1H, s), 3.81, 3.73 (2H,2s), 3.75 (3H, s), 2.21 (3H, s).

後処理

  1. filtrationThe mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-5774c3dfd7d147e1ba0495209d37260a
出典データセット
uspto-grants-2006_05
特許番号
US07053107B2

反応ノート

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