Phenothiazine → 9-[(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)methyl]phenothiazine

HRID 1827712ノート

反応式

HRID 1827712 の反応式
NC1N=C(N)C2C(CN(C3C=CC=CC=3)C3C=CC=CC=3)=CSC=2N=1.[NH2:26][C:27]1[N:28]=[C:29]([NH2:37])[C:30]2[C:35]([CH3:36])=[CH:34][S:33][C:31]=2[N:32]=1.[CH:38]1[C:51]2[NH:50][C:49]3[C:44](=[CH:45][CH:46]=[CH:47][CH:48]=3)[S:43][C:42]=2[CH:41]=[CH:40][CH:39]=1>>[NH2:26][C:27]1[N:28]=[C:29]([NH2:37])[C:30]2[C:35]([CH2:36][C:48]3[CH:47]=[CH:46][CH:45]=[C:44]4[C:49]=3[NH:50][C:51]3[CH:38]=[CH:39][CH:40]=[CH:41][C:42]=3[S:43]4)=[CH:34][S:33][C:31]=2[N:32]=1

参加物

4

反応物 3

HCID 7108PhenothiazineHCID 9906281n-[(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)methyl]-n,n-diphenylamineHCID 12659534Thieno[2,3-d]pyrimidine-2,4-diamine, 5-methyl-

生成物 1

HCID 220630199-[(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)methyl]phenothiazine

実験手順

9-[(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)methyl]phenothiazine (Formula I: Ar=2,4-diaminothieno[2,3-d]pyrimidin-5-yl; W=CH2; X=N; Z=S; m=n=0) is prepared similarly to N-[(2,4-diaminothieno[2,3-d]pyrimidin-5-yl)methyl]-N,N-diphenylamine as disclosed in Example 11 above by using 2,4-diamino-5-methylthieno[2,3-d]pyrimidine (1.3 g, 7.4 mmol) in Step 1 and phenothiazine (159 mg, 0.8 mmol) in Step 3. The final product and its intermediates can be purified by chromatography.

後処理

  1. customThe final product and its intermediates can be purified by chromatography

出典と根拠

ORDレコード
ord-fe20ee7f059d456c93876ee6f0635ffe
出典データセット
uspto-grants-2006_06
特許番号
US07056911B1

反応ノート

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