Lithium Hydroxide → HCID 178418698、化合物
反応式
[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:16])=[CH:7][C:8]([C:12]([O:14]C)=[O:13])=[N:9]2)=[CH:4][CH:3]=1.[Li+].[OH-]>CO.O>[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:16])=[CH:7][C:8]([C:12]([OH:14])=[O:13])=[N:9]2)=[CH:4][CH:3]=1参加物
5
実験手順
7-methyl-4-hydroxy-2-methoxycarbonylquinoline (6.45 g, 30.14 mmol) was suspended in MeOH (150 mL) and water (100 mL), and LiOH (3.08 g, 75.5 mmol) was added and stirred at ambient temperature for 2 hours. The methanol was evaporated in vacuo and residue was crystallized by addition of 2N hydrochloric acid. The resulting solid was filtered, washed with water and dried to afford 7-methyl-4-hydroxy-2-carboxyquinoline (6.0 g, 98%), NMR (DMSO-d6) 2.40 (s, 3), 6.68 (s, 1), 7.22 (d, 1), 7.68 (s, 1), 7.96 (d, 1).
後処理
- customThe methanol was evaporated in vacuo and residue
- customwas crystallized by addition of 2N hydrochloric acid
- filtrationThe resulting solid was filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-93a774023cdc4cb386cf72cd8882704b
- 出典データセット
- uspto-grants-2006_06
- 特許番号
- US07056923B2
反応ノート
読み込み中…