2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → Methyl 2-(4-(trifluoromethyl)phenyl)oxazole-4-carboxylate

HRID 1827884ノート

反応式

HRID 1827884 の反応式
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][CH2:11][CH:12]([C:14]([O:16][CH3:17])=[O:15])[N:13]=2)=[CH:5][CH:4]=1.ClC1C(=O)C(C#N)=C(C#N)C(=O)C=1Cl>C1(C)C=CC=CC=1>[F:19][C:2]([F:1])([F:18])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:10][CH:11]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[N:13]=2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 22064303Methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate

生成物 1

HCID 22064320Methyl 2-(4-(trifluoromethyl)phenyl)oxazole-4-carboxylate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
75 °C

実験手順

A solution of methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate (1.33 g, 4.87 mmol) was stirred in toluene (60 ml) at 55° C. until all of the starting material was dissolved. 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (5.53 g, 24.365 mmol) was then added in portions, and the resulting solution was stirred at 75° C. for 36 hours. The solvent was evaporated under reduced pressure, and the residue was purified by column chromatography, to provide methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazole-4-carboxylate, a compound of formula (15).

後処理

  1. dissolutionwas dissolved
  2. customThe solvent was evaporated under reduced pressure
  3. customthe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-08aafadff4434e1f8d113f08e9462601
出典データセット
uspto-grants-2006_06
特許番号
US07056924B2

反応ノート

読み込み中…