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Methyl (R)-(+)-2-isocyanato-3-phenylpropionate → (R)-2-(4-Phenoxymethyl-benzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl (R)-(+)-2-isocyanato-3-phenylpropionate | HCID 6558897 | — |
| 反応物 | (4-(Phenoxymethyl)phenyl)methanol | HCID 11333367 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 生成物 | (R)-2-(4-Phenoxymethyl-benzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester | HCID 12990904 | 95.4% |
反応手順
4-Phenoxymethylphenylmethanol 4 (0.857 g, 4.0 mmol), (R)-2-isocyanato-3-phenyl-propionic acid methyl ester 5 (1.026 g, 5.0 mmol) and 4-dimethylaminopyridine (DMAP) (10 mg) were combined, heated until molten, and stirred for 20 min. Upon cooling, the residue was purified by chromatography to give about 1.6 g of (R)-2-(4-phenoxymethyl-benzyloxycarbonylamino)-3-phenyl-propionic acid methyl ester 6.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07056903B2 |
| 出典データセット | uspto-grants-2006_06 |
| ORD ID | ord-13b93bb077cb49369b30162400705b29 |
| 出典メモ | uspto-grants-2006_06 |