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HRID1827962

反应详情

EQUATION

反应方程式

HRID 1827962 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)[C@@H](Cc1ccccc1)N=C=O
HCID6558897

Methyl (R)-(+)-2-isocyanato-3-phenylpropionate

C11H11NO3

结构：OCc1ccc(COc2ccccc2)cc1
HCID11333367

[4-(phenoxymethyl)phenyl]methanol

C14H14O2

PRODUCTS

生成物

1
结构：COC(=O)[C@@H](Cc1ccccc1)NC(=O)OCc1ccc(COc2ccccc2)cc1
HCID12990904

未命名化合物

收率 95.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

PROCEDURE

实验过程

4-Phenoxymethylphenylmethanol 4 (0.857 g, 4.0 mmol), (R)-2-isocyanato-3-phenyl-propionic acid methyl ester 5 (1.026 g, 5.0 mmol) and 4-dimethylaminopyridine (DMAP) (10 mg) were combined, heated until molten, and stirred for 20 min. Upon cooling, the residue was purified by chromatography to give about 1.6 g of (R)-2-(4-phenoxymethyl-benzyloxycarbonylamino)-3-phenyl-propionic acid methyl ester 6.

WORKUP

后处理

  1. temperatureheated
  2. temperatureUpon cooling
  3. customthe residue was purified by chromatography