tert-Butyl [2-(pyridin-2-yl)ethyl]carbamate → tert-Butyl (2-(piperidin-2-yl)ethyl)carbamate

HRID 1828041ノート

反応式

HRID 1828041 の反応式
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CC(O)=O.O=[Pt]=O>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][NH:12]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 1

HCID 22027815tert-Butyl [2-(pyridin-2-yl)ethyl]carbamate

生成物 1

HCID 5001226tert-Butyl (2-(piperidin-2-yl)ethyl)carbamate

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 176Acetic Acid溶媒

実験手順

The product from step A was mixed with PtO2 (640 mg) in HOAc (30 mL) and hydrogenation was carried out at 58 psi on a Parr apparatus for overnight. Catalyst was removed and solvent was evaporated under reduced pressure to give N-t-butoxycarbonyl 2-(piperidin-2-yl) ethylamine as a black liquid.

後処理

  1. customCatalyst was removed
  2. customsolvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-635313394ca24fa39a96735fe4b012e3
出典データセット
uspto-grants-2006_06
特許番号
US07056937B2

反応ノート

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