HCID 69585825、化合物 → HCID 62414059、化合物
反応式
[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]2[CH2:14][CH2:13][CH2:12]2)=[C:6]([N+:15]([O-])=O)[CH:5]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]2[CH2:14][CH2:13][CH2:12]2)=[C:6]([NH2:15])[CH:5]=1参加物
4
実験手順
To a solution of 4-cyclobutylamino-3-nitro-benzoic acid methyl ester (18.959, 56.3 mmol) in ethyl alcohol (300 ml) in a Parr shaker was added 10% Pd/C (0.67 g). The reaction was subjected to an atmosphere of hydrogen (50 psi) until the consumption of hydrogen ceased (2 hours). The reaction mixture was filtered through a pad of Celite® and concentrated to give 15.94 g of 3-Amino-4-cyclobutylamino-benzoic acid methyl ester as a solid.
後処理
- customThe reaction was subjected to an atmosphere of hydrogen (50 psi) until the consumption of hydrogen
- custom(2 hours)
- filtrationThe reaction mixture was filtered through a pad of Celite®
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-f509f8a49a13445982d6ba3052c3073d
- 出典データセット
- uspto-grants-2006_06
- 特許番号
- US07056918B2
反応ノート
読み込み中…