Thionyl Chloride → HCID 22063674、化合物

反応式

[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[N:12]=[N:11][C:10]([CH2:13][C:14](O)=[O:15])=[N:9]2)=[CH:5][CH:4]=1.S(Cl)([Cl:21])=O>>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[N:12]=[N:11][C:10]([CH2:13][C:14]([Cl:21])=[O:15])=[N:9]2)=[CH:5][CH:4]=1

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 22063596HCID 22063596、化合物2 回

生成物 1

HCID 22063674HCID 22063674、化合物収率 96.4%

実験手順

The 2-[2-(4-methoxybenzyl)-2H-1,2,3,4-tetrazol-5-yl]acetic acid (262.0 mg, 1.05 mmol) obtained in (B) was added dropwise with thionyl chloride (615.9 μl, 8.44 mmol) under ice cooling and stirred at room temperature for 30 minutes. Excessive regents were evaporated to obtain the title compound (0.27 g, quantitative) as pale yellow oil.

後処理

customExcessive regents were evaporated

出典と根拠

ORDレコード: ord-08b46b59e2174ea58b9815c8042100ae
出典データセット: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07056917B2

反応ノート

読み込み中…

参加物