Cornforth reagent → 4-Isopropyl-1,3-thiazole-2-carbaldehyde
反応式
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][OH:10])[S:7][CH:8]=1)([CH3:3])[CH3:2].[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1>C(Cl)Cl>[CH:1]([C:4]1[N:5]=[C:6]([CH:9]=[O:10])[S:7][CH:8]=1)([CH3:3])[CH3:2]参加物
4
実験手順
(4-Isopropyl-1,3-thiazol-2-yl)methanol (5.20 g, 33.0 mmol) was dissolved in methylene chloride (100 ml), added with pyridinium dichromate (14.9 g, 39.7 mmol), and stirred at room temperature for 19 hours stirred. After insoluble solids were removed, the reaction solution was evaporated, and the residue was purified by silica gel column chromatography (chloroform) to obtain the title compound (3.32 g, 65%).
後処理
- stirringstirred
- customAfter insoluble solids were removed
- customthe reaction solution was evaporated
- customthe residue was purified by silica gel column chromatography (chloroform)
出典と根拠
- ORDレコード
- ord-65216ea3f17e430f8a4a8ad03ee8d428
- 出典データセット
- uspto-grants-2006_06
- 特許番号
- US07056917B2
反応ノート
読み込み中…