Anisole → HCID 178439804、化合物

HRID 1828513ノート

反応式

HRID 1828513 の反応式
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:41]=[CH:40][N:14]3[C:15](=[O:39])[C:16]([C:25]4[N:29](CC5C=CC(OC)=CC=5)[N:28]=[N:27][N:26]=4)=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2].C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:41]=[CH:40][N:14]3[C:15](=[O:39])[C:16]([C:25]4[NH:29][N:28]=[N:27][N:26]=4)=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 7519AnisoleHCID 696031968-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl)-2-morpholino-3-(1-p-methoxybenzyl-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one2 回

生成物 1

HCID 178439804HCID 178439804、化合物収率 88.6%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

The 8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-morpholino-3-(1-p-methoxybenzyl-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one (10 mg) obtained in (C) was dissolved in trifluoroacetic acid (1 ml) and added with anisole (50 ml), and then stirred at room temperature for 4 hours. After the solvent was evaporated, the residue was purified by silica gel column chromatography to obtain the title compound (7 mg) as yellow powder.

後処理

  1. customAfter the solvent was evaporated
  2. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-6a300be324554dae880183e637b2b981
出典データセット
uspto-grants-2006_06
特許番号
US07056917B2

反応ノート

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