Aluminium lithium hydride → 1-Azabicyclo(2.2.2)octane-4-methanol
反応式
Cl.[N:2]12[CH2:9][CH2:8][C:5]([C:10](O)=[O:11])([CH2:6][CH2:7]1)[CH2:4][CH2:3]2.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[N:2]12[CH2:9][CH2:8][C:5]([CH2:10][OH:11])([CH2:6][CH2:7]1)[CH2:4][CH2:3]2参加物
4
実験手順
Quinuclidine-4-carboxylic acid hydrochloride (3.0 g, 0.016 moles) was treated with lithium aluminium hydride (2.5 g, 0.066 moles) in tetrahydrofuran (150 ml) at ambient temperature for 18 hours. The reaction was worked up as in the method of Example 25 Step 1 to give the title compound 2.24 g (100%). MS (+ve electrospray) m/z 142 (MH+, 100%).
出典と根拠
- ORDレコード
- ord-829e52cdf54c49dfab01f87c7ef79d8c
- 出典データセット
- uspto-grants-2006_06
- 特許番号
- USRE039128E1
反応ノート
読み込み中…