Hydrogen Bromide → 4-(2-(Ethylamino)propyl)-1,2-benzenediol hydrobromide

HRID 1828969ノート

反応式

HRID 1828969 の反応式
C[O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([NH:14][CH2:15][CH3:16])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9]C.[BrH:17]>>[BrH:17].[CH2:15]([NH:14][CH:12]([CH3:13])[CH2:11][C:5]1[CH:4]=[C:3]([OH:2])[C:8]([OH:9])=[CH:7][CH:6]=1)[CH3:16]

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 22061570[2-(3,4-Dimethoxy-phenyl)-1-methyl-ethyl]-ethyl amine

生成物 1

HCID 1303564-(2-(Ethylamino)propyl)-1,2-benzenediol hydrobromide

実験手順

A solution of 1.1 g (4.92 mmol) of 2A in 10 mL of 48% HBr was heated to reflux under argon atmosphere for 3.5 hours and then concentrated to dryness under reduced pressure. To this was added 50 mL of dichloromethane and concentrated to dryness under reduced pressure to give crude 2B as a dark brown powder (M+Na, 318).

後処理

  1. temperatureto reflux under argon atmosphere for 3.5 hours
  2. concentrationconcentrated to dryness under reduced pressure
  3. additionTo this was added 50 mL of dichloromethane
  4. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-77d7e3110a764e9292a3c1dbb67f5612
出典データセット
uspto-grants-2006_06
特許番号
US07060847B2

反応ノート

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