Diethanolamine → 4-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline

HRID 1829154

反応式

HRID 1829154 の反応式
[NH:1]([CH2:5][CH2:6][OH:7])[CH2:2][CH2:3][OH:4].Cl[C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=[C:11]([C:19]([F:22])([F:21])[F:20])[CH:10]=1>[Cl-].[Na+].O>[OH:4][CH2:3][CH2:2][N:1]([C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=[C:11]([C:19]([F:22])([F:20])[F:21])[CH:10]=1)[CH2:5][CH2:6][OH:7]

参加物

4

反応物 2

HCID 8113DiethanolamineHCID 27367094-Chloro-2-(trifluoromethyl)quinoline

生成物 1

HCID 220288874-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline

試薬・触媒・溶媒 1

HCID 57417360Sodium chloride; water溶媒

反応条件

温度
80 °C

実験手順

Diethanolamine (20 mL) was added to 4-chloro-2-trifluoromethylquinoline (5.04 g), and the mixture was stirred at 80° C. for 19 hr. Brine was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was dried and concentrated under reduced pressure. The residue was purified by silica gel chromatography to give 4-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline (3.40 g) as a white powder.

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. customThe extract was dried
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-5a12686d5b184c17957184f36a38ae38
出典データセット
uspto-grants-2006_06
特許番号
US07060722B2

関連ノート

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