Methyl Isocyanate → 1-Benzyl-4-piperidinyl Methylcarbamate

HRID 1829185

反応式

HRID 1829185 の反応式
[CH3:1][N:2]=[C:3]=[O:4].[CH2:5]([N:12]1[CH2:17][CH2:16][CH:15]([OH:18])[CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(Cl)(Cl)Cl>[CH3:1][NH:2][C:3](=[O:4])[O:18][CH:15]1[CH2:16][CH2:17][N:12]([CH2:5][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:13][CH2:14]1

参加物

4

反応物 2

HCID 12228Methyl IsocyanateHCID 784611-Benzylpiperidin-4-ol

生成物 1

HCID 210299101-Benzyl-4-piperidinyl Methylcarbamate

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Methyl isocyanate (8.94 g, 157 mmol) was added to a solution of 1-benzyl-4-piperidinol (10 g, 52.3 mmol) in chloroform (80 ml), and the reaction stirred under reflux for 16 hours. The cooled mixture was concentrated under reduced pressure, the residual solid was triturated from 40–60 petroleum ether, and the product filtered and dried to afford the title compound as a white solid, 1 g. m.p.—106–108° C.

後処理

  1. temperatureunder reflux for 16 hours
  2. concentrationThe cooled mixture was concentrated under reduced pressure
  3. customthe residual solid was triturated from 40–60 petroleum ether
  4. filtrationthe product filtered
  5. customdried

出典と根拠

ORDレコード
ord-514def51315f4b51927da02412393b9c
出典データセット
uspto-grants-2006_06
特許番号
US07060836B2

関連ノート

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