Pyrrolidine → HCID 11195876、化合物

反応式

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][OH:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:14])[CH:3]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH3:14][C:4]1[CH:3]=[C:2]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[C:11]2[C:6](=[CH:7][C:8]([CH2:12][OH:13])=[CH:9][CH:10]=2)[N:5]=1

参加物

反応物 2

HCID 31268Pyrrolidine

HCID 11264243HCID 11264243、化合物

生成物 1

HCID 11195876HCID 11195876、化合物収率 90%

実験手順

(4-Chloro-2-methyl-quinolin-7-yl)-methanol (750 mg, 3.61 mmol) was refluxed in pyrrolidine (6.42 g, 90.3 mmol) for 16 h. Most of the pyrrolidine was then removed under reduced pressure, the oily residue was taken up in toluene, evaporated, and the solid obtained triturated in ethyl acetate, filtered and dried to afford the title compound (785 mg, 90%). Light brown solid, ISP-MS: m/e==243.3 ([M+H]+).

後処理

customMost of the pyrrolidine was then removed under reduced pressure
customevaporated
customthe solid obtained
customtriturated in ethyl acetate
filtrationfiltered
customdried

出典と根拠

ORDレコード: ord-a296ae48ae4c41388521aafdf9f34202
出典データセット: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07064134B2

反応ノート

読み込み中…

参加物