(1,4-Dibenzylpiperazin-2-yl)-N,N-dimethylmethanamine → N,N-dimethyl-2-piperazinemethanamine
反応式
C([N:8]1[CH2:13][CH2:12][N:11](CC2C=CC=CC=2)[CH2:10][CH:9]1[CH2:21][N:22]([CH3:24])[CH3:23])C1C=CC=CC=1>CCO.[Pd]>[CH3:23][N:22]([CH3:24])[CH2:21][CH:9]1[CH2:10][NH:11][CH2:12][CH2:13][NH:8]1参加物
4
反応条件
- 温度
- 130 °C
実験手順
{[1,4-bisbenzylpiperazin-2-yl]methyl}dimethylamine (1 equivalent), was dissolved in EtOH and the solution was transferred to a stainless steel high pressure vessel equipped with a pressure gauge. 10% Pd/C was added (10 wt. %), and the vessel charged with H2. The reaction mixture was stirred at 130° C. and 200 psi of H2 overnight. The reaction mixture was cooled to room temperature, filtered over a pad of Celite, and then evaporated. The desired amine was obtained in quantitative yield as a pale yellow oil. GC/MS: 143 (10%, M+), Rt=14.3 minutes.