Thionyl Chloride → Ethyl 4-(3-chlorophenyl)-6-[chloro(4-phenyl-2-thiazolyl)methyl]-1,2-dihydro-2-oxo-3-quinolinecarboxylate
反応式
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:7]=[C:8]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([CH:22](O)[C:23]4[S:24][CH:25]=[C:26]([C:28]5[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=5)[N:27]=4)[CH:20]=3)[NH:15][C:14](=[O:35])[C:13]=2[C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH:9]=[CH:10][CH:11]=1>C(Cl)Cl>[Cl:5][C:6]1[CH:7]=[C:8]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([CH:22]([Cl:3])[C:23]4[S:24][CH:25]=[C:26]([C:28]5[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=5)[N:27]=4)[CH:20]=3)[NH:15][C:14](=[O:35])[C:13]=2[C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH:9]=[CH:10][CH:11]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
Thionyl chloride (30 ml) was added dropwise to a mixture of intermediate (19) (0.0245 mol) in DCM (150 ml), previously cooled on an ice bath. The mixture was stirred at a low temperature for 1 hour and at room temperature overnight. The solvent was evaporated till dryness. The product was used without further purification, yielding (quant.) of ethyl 4-(3-chlorophenyl)-6-[chloro(4-phenyl-2-thiazolyl)methyl]-1,2-dihydro-2-oxo-3-quinolinecarboxylate (intermediate 20).