Methylamine → 3-Cyano-N-methylbenzamide

HRID 1830874ノート

反応式

HRID 1830874 の反応式
[CH3:1][NH2:2].[C:3]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8](Cl)=[O:9])#[N:4]>C1COCC1>[C:3]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([NH:2][CH3:1])=[O:9])#[N:4]

参加物

4

反応物 2

HCID 6329MethylamineHCID 3084833-Cyanobenzoyl chloride

生成物 1

HCID 220496963-Cyano-N-methylbenzamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
5 °C

実験手順

A mixture of 40% aqueous methylamine solution (20 ml) and THF (30 ml) was cooled to 5° C., and 3-cyanobenzoyl chloride (1.89 g) was slowly added. The mixture was stirred for one hr. The reaction mixture was extracted with ethyl acetate, and the organic layer was dried and concentrated. The residue was recrystallized from ethyl acetate to give the title compound (1.14 g) as colorless needle crystals.

後処理

  1. extractionThe reaction mixture was extracted with ethyl acetate
  2. customthe organic layer was dried
  3. concentrationconcentrated
  4. customThe residue was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-f0ba064e98704e17b2865c55a6045f08
出典データセット
uspto-grants-2006_06
特許番号
US07067537B2

反応ノート

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