4-Sulfamoylthiobenzamide → 4-[5-Methyl-4-(4-methylpyridin-3-yl)-1,3-thiazol-2-yl]benzenesulfonamide

HRID 1830901

反応式

HRID 1830901 の反応式
Br[CH:2]([CH3:12])[C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.[NH2:13][S:14]([C:17]1[CH:22]=[CH:21][C:20]([C:23](=[S:25])[NH2:24])=[CH:19][CH:18]=1)(=[O:16])=[O:15]>>[CH3:12][C:2]1[S:25][C:23]([C:20]2[CH:19]=[CH:18][C:17]([S:14]([NH2:13])(=[O:15])=[O:16])=[CH:22][CH:21]=2)=[N:24][C:3]=1[C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11]

参加物

3

反応物 2

HCID 30032664-SulfamoylthiobenzamideHCID 220497622-Bromo-1-(4-methylpyridin-3-yl)propan-1-one

生成物 1

HCID 220497554-[5-Methyl-4-(4-methylpyridin-3-yl)-1,3-thiazol-2-yl]benzenesulfonamide収率 56.8%

実験手順

By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-methylpyridin-3-yl)propan-1-one hydrobromate (510 mg) and 4-(aminosulfonyl)benzenecarbothioamide (355 mg), the title compound (322 mg) was obtained as colorless powder crystals.

後処理

  1. customBy the reaction in the same manner as in Example 25-iii)

出典と根拠

ORDレコード
ord-ce545a3b15d4460abeb2f3e5f13ee968
出典データセット
uspto-grants-2006_06
特許番号
US07067537B2

関連ノート

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