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4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol → 4-Benzyl-piperidine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol | HCID 155241 | — |
| 反応物 | 1-methyl-3-(4-benzyl-piperidine-1-carbonyl)-3H-imidazol-1-ium iodide | HCID 86589190 | — |
| 生成物 | 4-Benzyl-piperidine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester | HCID 23635636 | — |
反応手順
The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenol and 1-methyl-3-(4-benzyl-piperidine-1-carbonyl)-3H-imidazol-1-ium iodide. The crude product was purified by flash chromatography using a Quad flash 25 (ethyl acetate/heptane (1:6), (72%, white crystals). HPLC-MS m/z=457.2 (M+1), Rt: 6.0 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07067517B2 |
| 出典データセット | uspto-grants-2006_06 |
| ORD ID | ord-ab67c03345434f0c9e963b367cff9ad4 |
| 出典メモ | uspto-grants-2006_06 |