2-(Benzyloxy)-4-(2,4-dichlorophenyl)-3-nitropyridine → 4-(2,4-dichloro-phenyl)-3-nitro-1H-pyridin-2-one

HRID 1831505ノート

反応式

HRID 1831505 の反応式
C([O:8][C:9]1[C:14]([N+:15]([O-:17])=[O:16])=[C:13]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=2[Cl:25])[CH:12]=[CH:11][N:10]=1)C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[Cl:25][C:19]1[CH:20]=[C:21]([Cl:24])[CH:22]=[CH:23][C:18]=1[C:13]1[CH:12]=[CH:11][NH:10][C:9](=[O:8])[C:14]=1[N+:15]([O-:17])=[O:16]

参加物

3

反応物 1

HCID 220521282-(Benzyloxy)-4-(2,4-dichlorophenyl)-3-nitropyridine

生成物 1

HCID 220520964-(2,4-dichloro-phenyl)-3-nitro-1H-pyridin-2-one収率 23%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

2-Benzyloxy-4-(2,4-dichloro-phenyl)-3-nitro-pyridine (5.79 g, 15.4 mmol) was dissolved in TFA (20 mL) and stirred at room temperature for 4 h. The reaction mixture was concentrated and washed with 20% EtOAc/Hexane, and concentrated in vacuo to yield 1.0 g (23%) of 4-(2,4-dichloro-phenyl)-3-nitro-1H-pyridin-2-one as a solid: crude MS (AP) m/z 285.1 [(M+H)+, 100].

後処理

  1. concentrationThe reaction mixture was concentrated
  2. washwashed with 20% EtOAc/Hexane
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-6767736011bb4d2ba9ce209c608b1032
出典データセット
uspto-grants-2006_06
特許番号
US07067658B2

反応ノート

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