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Lithium hydroxide, monohydrate → 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium hydroxide, monohydrate | HCID 168937 | — |
| 反応物 | 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic acid methyl ester | HCID 69652265 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic Acid | HCID 22052488 | — |
反応手順
To a solution of 400 mg 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic acid methyl ester in 5 ml MeOH/H2O 2:1 56 mg lithium hydroxide monohydrate were added and the mixture was stirred over night. The suspension was diluted with 5 ml concentrated HCl to precipitate the acid. After filtration the filter cake was washed twice with water and then dried to yield the acid as a white powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07067665B2 |
| 出典データセット | uspto-grants-2006_06 |
| ORD ID | ord-69c7a0c252af43e5b0a9aa16263b32a2 |
| 出典メモ | uspto-grants-2006_06 |