N-bromobutanimide → HCID 22049892、化合物

HRID 1832058ノート

反応式

HRID 1832058 の反応式
[F:1][C:2]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:3]=1[CH2:4][O:5][C:6]1[CH:11]=[C:10]([CH3:12])[N:9]([C:13]2[CH:14]=[C:15]([CH:20]=[CH:21][C:22]=2[CH3:23])[C:16]([O:18][CH3:19])=[O:17])[C:8](=[O:24])[CH:7]=1.[Br:30]N1C(=O)CCC1=O>C(Cl)Cl>[Br:30][C:7]1[C:8](=[O:24])[N:9]([C:13]2[CH:14]=[C:15]([CH:20]=[CH:21][C:22]=2[CH3:23])[C:16]([O:18][CH3:19])=[O:17])[C:10]([CH3:12])=[CH:11][C:6]=1[O:5][CH2:4][C:3]1[CH:25]=[CH:26][C:27]([F:29])=[CH:28][C:2]=1[F:1]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 22050431HCID 22050431、化合物

生成物 1

HCID 22049892HCID 22049892、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Methyl 3-[4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl]-4-methylbenzoate (as prepared above) (1.8 g, 4.51 mmol) was taken up in CH2Cl2 (10 ml). N-bromosuccinimide (0.80 g, 4.51 mmol) was added and the mixture stirred at room temperature for two hours. The CH2Cl2 is removed in vacuo and the residue is taken up in CH3CN. The resulting precipitate is collected on a filter pad and washed with CH3CN to yield a white solid (0.30 g, 14%, first crop)

後処理

  1. customThe CH2Cl2 is removed in vacuo
  2. customThe resulting precipitate is collected on a filter pad
  3. washwashed with CH3CN
  4. customto yield a white solid (0.30 g, 14%, first crop)

出典と根拠

ORDレコード
ord-601137475a874b5fa68a597f5fb0ac38
出典データセット
uspto-grants-2006_06
特許番号
US07067540B2

反応ノート

読み込み中…