6-Butoxy-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde → 6-Butoxy-7-methoxy-1-(3-methoxy-benzyl)-isoquinoline-4-carbaldehyde

HRID 1833150ノート

反応式

HRID 1833150 の反応式
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH3:17])[CH:12]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=1)[NH:11][CH:10]=[C:9]2[CH:27]=[O:28])[CH2:2][CH2:3][CH3:4]>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[CH2:1]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH3:17])[C:12]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=1)=[N:11][CH:10]=[C:9]2[CH:27]=[O:28])[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 1

HCID 220482446-Butoxy-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde

生成物 1

HCID 220482946-Butoxy-7-methoxy-1-(3-methoxy-benzyl)-isoquinoline-4-carbaldehyde収率 99.4%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

To a stirred solution of 6-butoxy-7-methoxy-1-(3-methoxy-benzyl)-1,2-dihydro-isoquinoline-4-carbaldehyde (200 mg, 0.53 mmol) in chloroform (6 mL) was added manganese (IV) oxide (536 mg, 5.34 mmol). The reaction mixture was stirred at room temperature for 15 hrs, filtered through a Celite® pad, and washed with chloroform. The filtrate was concentrated in vacuo to afford 6-butoxy-7-methoxy-1-(3-methoxy-benzyl)-isoquinoline-4-carbaldehyde (200 mg, 99% yield). The crude product was without further purification.

後処理

  1. filtrationfiltered through a Celite® pad
  2. washwashed with chloroform
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-3c570257739e4920be79cdda374406db
出典データセット
uspto-grants-2006_06
特許番号
US07067529B2

反応ノート

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