HCID 69551824、化合物 → HCID 69551823、化合物
反応式
[CH2:1]([O:3][C:4]([CH:6]1[C:15]2[C:10](=[CH:11][C:12]([O:18][CH3:19])=[C:13]([O:16][CH3:17])[CH:14]=2)[C:9]([CH2:20][C:21]2[CH:26]=[C:25]([CH3:27])[CH:24]=[C:23]([O:28][CH3:29])[CH:22]=2)=[N:8][CH2:7]1)=[O:5])[CH3:2]>[Pd].C1(C)C(C)=CC=CC=1>[CH2:1]([O:3][C:4]([C:6]1[C:15]2[C:10](=[CH:11][C:12]([O:18][CH3:19])=[C:13]([O:16][CH3:17])[CH:14]=2)[C:9]([CH2:20][C:21]2[CH:26]=[C:25]([CH3:27])[CH:24]=[C:23]([O:28][CH3:29])[CH:22]=2)=[N:8][CH:7]=1)=[O:5])[CH3:2]参加物
4
実験手順
A solution of 6,7-dimethoxy-1-(3-methoxy-5-methyl-benzyl)-3,4-dihydro-isoquinoline-4-carboxylic acid ethyl ester (0.73 g, 1.8 mmol) and 10% palladium on carbon (230 mg) in xylene (15 mL) was refluxed overnight. The reaction mixture was cooled, filtered through celite, and concentrated in vacuo to afford 6,7-dimethoxy-1-(3-methoxy-5-methyl-benzyl)-isoquinoline-4-carboxylic acid ethyl ester as a light brown oil (0.63 g, 89%). This material was used without further purification: 1H NMR (300 MHz) compatible.