Ethanol → 5-Ethoxy-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine

HRID 1833343ノート

反応式

HRID 1833343 の反応式
Cl[C:2]1[C:7]2[CH:8]=[N:9][CH:10]=[CH:11][C:6]=2[N:5]2[N:12]=[C:13]([CH3:15])[CH:14]=[C:4]2[N:3]=1.[Na].[CH2:17]([OH:19])[CH3:18]>O>[CH2:17]([O:19][C:2]1[C:7]2[CH:8]=[N:9][CH:10]=[CH:11][C:6]=2[N:5]2[N:12]=[C:13]([CH3:15])[CH:14]=[C:4]2[N:3]=1)[CH3:18]

参加物

5

反応物 3

HCID 702EthanolHCID 5360545SodiumHCID 213891855-Chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine

生成物 1

HCID 213891755-Ethoxy-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2.2 g. of 5-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine are added to a solution of 0.5 g. of sodium in 30 ml. of ethanol. The solution is refluxed with stirring for 12 hours. 10 ml. of water are added and the crystalline 5-ethoxy-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine is filtered off, yield: 1.4 g. (61%); m.p. 156.2° (methanol).

後処理

  1. temperatureThe solution is refluxed
  2. filtrationthe crystalline 5-ethoxy-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine is filtered off

出典と根拠

ORDレコード
ord-0d9d9bffcc0f401e8a1d1b162124b44d
出典データセット
uspto-grants-1978_01
特許番号
US04066645

反応ノート

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