Butylamine → N-Butyl-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-amine
反応式
Cl[C:2]1[C:7]2[CH:8]=[N:9][CH:10]=[CH:11][C:6]=2[N:5]2[N:12]=[C:13]([CH3:15])[CH:14]=[C:4]2[N:3]=1.[CH2:16]([NH2:20])[CH2:17][CH2:18][CH3:19]>>[CH2:16]([NH:20][C:2]1[C:7]2[CH:8]=[N:9][CH:10]=[CH:11][C:6]=2[N:5]2[N:12]=[C:13]([CH3:15])[CH:14]=[C:4]2[N:3]=1)[CH2:17][CH2:18][CH3:19]参加物
3
実験手順
2.2 g. of 5-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine of Example 18 are refluxed in 10 ml. of n-butylamine for 12 hours. The excess amine is evaporated and the residue treated with 10 ml. of water. N-Butyl-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-amine is filtered off, yield: 2 g. (80%); m.p. 116.1° (methanol).
後処理
- customThe excess amine is evaporated
- additionthe residue treated with 10 ml
- filtrationN-Butyl-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-amine is filtered off
出典と根拠
- ORDレコード
- ord-ac054abd91924b8ea2013aa473bbef05
- 出典データセット
- uspto-grants-1978_01
- 特許番号
- US04066645
反応ノート
読み込み中…