Sodium Hydroxide → HCID 54012521、化合物
反応式
[CH2:1]([N:3]1[CH2:10][CH:9]2[CH:5]([CH2:6][CH2:7][CH2:8]2)[CH:4]1[CH2:11][NH:12][C:13](=[O:27])[C:14]1[CH:19]=[C:18]([Cl:20])[C:17]([NH:21]C(=O)C)=[CH:16][C:15]=1[O:25][CH3:26])[CH3:2].[OH-].[Na+]>C(O)C>[CH2:1]([N:3]1[CH2:10][CH:9]2[CH:5]([CH2:6][CH2:7][CH2:8]2)[CH:4]1[CH2:11][NH:12][C:13](=[O:27])[C:14]1[CH:19]=[C:18]([Cl:20])[C:17]([NH2:21])=[CH:16][C:15]=1[O:25][CH3:26])[CH3:2]参加物
4
実験手順
7 parts of N-ethyl-2-(2-methoxy-4-acetylamino-5-chloro benzamido methyl)-3-azabicyclo (3,3,0) octane were heated for 30 minutes in the presence of 17.7 parts of a 2 N solution of sodium hydroxide and 15 parts of ethanol. After cooling, the precipitate was filtered and recrystallized in 40 parts of acetonitrile. There were obtained 5 parts of N-ethyl-2-(2-methoxy-4-amino-5-chloro benzamido methyl)-3-azabicyclo(3,3,0) octane, M.P. 128°-129° C.