Triethylamine → HCID 54015426、化合物

HRID 1833803ノート

反応式

HRID 1833803 の反応式
C(N(CC)CC)C.[OH:8][C:9]1[N:13]=[C:12]([O:14][CH2:15][CH3:16])[S:11][N:10]=1.[CH2:17]([O:19][CH2:20][CH2:21][N:22]=[C:23]=[O:24])[CH3:18]>O1CCCC1>[CH3:18][CH2:17][O:19][CH2:20][CH2:21][NH:22][C:23]([N:10]1[C:9](=[O:8])[N:13]=[C:12]([O:14][CH2:15][CH3:16])[S:11]1)=[O:24]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 12017510Ethane, 1-ethoxy-2-isocyanato-HCID 178467476HCID 178467476、化合物

生成物 1

HCID 54015426HCID 54015426、化合物収率 53.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
25 °C

実験手順

1 ml of triethylamine was added to a solution of 14.6 g of 3-hydroxy-5-ethoxy-1,2,4-thiadiazole in 140 ml of tetrahydrofuran and then 23 g of ethoxyethyl isocyanate were added dropwise. The mixture was stirred for 2 hours at 25° C and was concentrated to dryness. The residue was chromatographed over silica gel and elution with a 4-6 benzene-ethyl acetate mixture yielded 14 g of 2-(N-β-ethoxyethylcarbamoyl)-5-ethoxy-1,2,4-thiadiazole-3-one melting at <50° C.

後処理

  1. concentrationwas concentrated to dryness
  2. customThe residue was chromatographed over silica gel and elution with a 4-6 benzene-ethyl acetate mixture

出典と根拠

ORDレコード
ord-9213b0f913c043a9ba46597b136890e8
出典データセット
uspto-grants-1978_01
特許番号
US04067720

反応ノート

読み込み中…