Triethylamine → 5-Butoxy-N-methyl-3-oxo-1,2,4-thiadiazole-2(3H)-carboxamide

HRID 1833810ノート

反応式

HRID 1833810 の反応式
[CH3:1][N:2]=[C:3]=[O:4].[OH:5][C:6]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[S:8][N:7]=1.C(N(CC)CC)C>O1CCCC1>[CH3:1][NH:2][C:3]([N:7]1[C:6](=[O:5])[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[S:8]1)=[O:4]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 178450384HCID 178450384、化合物

生成物 1

HCID 213874945-Butoxy-N-methyl-3-oxo-1,2,4-thiadiazole-2(3H)-carboxamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
20 °C

実験手順

10 ml of methyl isocyanate were added to a solution of 17.5 g of 3-hydroxy-5-n-butoxy-1,2,4-thiadiazole in 125 ml of tetrahydrofuran containing 0.5 ml of triethylamine and after stirring for 2 hours at 20° C, the mixture was evaporated to dryness. The residue was empasted with isopropyl ether and was vacuum filtered and dried to obtain 21 g of 2-(N-methylcarbamoyl)-5-n-butoxy-1,2,4-thiadiazole-3-one melting at 108° C.

後処理

  1. customthe mixture was evaporated to dryness
  2. filtrationfiltered
  3. customdried

出典と根拠

ORDレコード
ord-b4991b8f46554a4c984acb8620c2c300
出典データセット
uspto-grants-1978_01
特許番号
US04067720

反応ノート

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