Magnesium monoxide → 3-Benzylpyridazine
反応式
Cl[CH:2]([C:9]1[N:10]=[N:11][CH:12]=[CH:13][CH:14]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[H][H].[O-2].[Mg+2]>C(O)C.[Pd]>[CH2:2]([C:9]1[N:10]=[N:11][CH:12]=[CH:13][CH:14]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1参加物
6
実験手順
A solution of (±) 3-α-chlorobenzylpyridazine (2.05 g.) in ethanol (50 ml.) was treated with hydrogen, in the presence of magnesium oxide (0.4 g.) and palladium on charcoal (5% Pd; 0.2 g.), for 1 hour at ambient temperature and normal atmospheric pressure. The solution was then filtered and the filtrate was evaporated to dryness. The residue was dissolved in hot chloroform (100 ml.), cooled, washed with water (50 ml.), dried over magnesium sulphate and evaporated to give 3-benzylpyridazine (1.6 g.), m.p. 61°-64° C., in the form of a light brown coloured solid.
後処理
- filtrationThe solution was then filtered
- customthe filtrate was evaporated to dryness
- dissolutionThe residue was dissolved in hot chloroform (100 ml.)
- temperaturecooled
- washwashed with water (50 ml.)
- dry with materialdried over magnesium sulphate
- customevaporated
出典と根拠
- ORDレコード
- ord-ab703a07c09346e8ab24ce79bed21700
- 出典データセット
- uspto-grants-1978_01
- 特許番号
- US04067723
反応ノート
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