Ethyl 4-(2-nitrophenyl)-3-oxobutanoate → Ethyl 2-(1H-indol-2-yl)acetate
反応式
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][C:6]([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-])=O)=O)[CH3:2]>[Pd].C(O)(=O)C>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][C:6]1[NH:15][C:10]2[C:9]([CH:8]=1)=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH3:2]参加物
4
実験手順
A sample of 12.0 gm (0.048M) of ethyl-γ-2-nitrophenylacetoacetate was dissolved in 200 cc. glacial acetic acid. Approximately 21/2 spatulas of 5% Pd/C was added to the solution and the compound was reduced on the Parr hydrogenator. Ethyl-2-indolylacetate was obtained as a dark orangy oily liquid after removal of catalyst and solvent.
出典と根拠
- ORDレコード
- ord-341fed9deb5a46a5a00ef3c7dc9ccab0
- 出典データセット
- uspto-grants-1978_01
- 特許番号
- US04067871
反応ノート
読み込み中…