1-Naphthol → N-(4-Ethoxyphenyl)naphthalen-1-amine

HRID 1833962ノート

反応式

HRID 1833962 の反応式
[C:1]1(O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[CH3:12][CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([NH2:21])=[CH:19][CH:20]=1.P(OCC1C=CC=CC=1)(OCC1C=CC=CC=1)OCC1C=CC=CC=1>O>[CH2:13]([O:14][C:15]1[CH:16]=[CH:17][C:18]([NH:21][C:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][CH:2]=2)=[CH:19][CH:20]=1)[CH3:12]

参加物

5

反応物 3

HCID 70051-NaphtholHCID 90764-EthoxyanilineHCID 11810300Tribenzyl phosphite

生成物 1

HCID 80716N-(4-Ethoxyphenyl)naphthalen-1-amine収率 91%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
218 °C

実験手順

288 parts of α-naphthol, 411 parts of p-phenetidine and 8 parts of tribenzyl phosphite are mixed and heated to 218° C. At this temperature, the elimination of water commences. The reaction temperature rises to 250° C in the course of 10 hours. At that stage, the reaction has ended and 36 parts of water have been removed. After removing excess p-phenetidine, the N-p-ethoxy-phenyl-α-naphthylamine distils at a boiling point of 233° - 235° C/5 mm Hg. 479 parts of end product of melting point 72° - 75° C are obtained. This corresponds to a yield of 91% of theory.

後処理

  1. customrises to 250° C in the course of 10 hours
  2. custom36 parts of water have been removed
  3. customAfter removing excess p-phenetidine
  4. customthe N-p-ethoxy-phenyl-α-naphthylamine distils at a boiling point of 233° - 235° C/5 mm Hg
  5. custom479 parts of end product of melting point 72° - 75° C are obtained

出典と根拠

ORDレコード
ord-572ccf88eb2c4232a6112045d42139fd
出典データセット
uspto-grants-1978_01
特許番号
US04067903

反応ノート

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